ABSTRACT
Pathophysiology teachers must find the keys of interdisciplinary cross penetration and focus on the link, contacts and differences between pathophysiology and other basic disciplines according to pathophysiolgy text and the law of students' cognitive development. Teachers should guide students to construct the contact figures between pathophysiology knowledge with other subjects of mutual by designing teaching contents and using the teaching method of interdisciplinary cross-penetration-based, clinical problem-oriented and integrations of teaching and research supplemented. Practice of multi-inter disciplinary cross penetration teaching mode in pathophysiology teaching is helpful to improving the teaching quality of pathology physiology and plays a certain role in activeat-ing studetns' study interest, perfecting their knowledge structure and stimulating their innovation awareness.